It'll be set in Boston, the cinematic trailer can be found here.
It appears to be in-engine, and the color scheme is very vivid. the Fallout 4 website already has pre-order options. Xbox 360 and PS3 do not appear to be options, making this purely a next-gen game. Graphics in the trailer aren't particularly impressive, but we'll have to wait and see.

More to be shown at E3....

So Bethesda just posted this on their Facebook and Twitter. It's the official Fallout site, with everything replaced by the classic Please Stand By Image, and a countdown that ends tomorrow at 10:00 am EST. This isn't Survivor 2277. Unless a very dedicated hacker took control of every Bethesda PR account ever, this may just be real. Will post updates on this thread as they come.

Morrowind May Modathon Month 2015
Celebrating Morrowind's 13th Anniversary


Description:
In the early days of May 2002, a little game came out called The Elder Scrolls III: Morrowind. It would go on to save Bethesda Softworks from bankruptcy, sell millions of copies, and become the most popular game for modding at the turn of the century. Now, 13 years later, over 22,000 mods have been released for Morrowind between Morrowind Nexus and GHF with the modding community still going...

My web page may soon become unavailable so I have uploaded my previously released Morrowind mods to Morrowind Modding History. As of the time of this post my mods are awaiting approval before they will...

Title: £exa's Dwemer Resources - Exterior Ruin Signs

Version: 1.00
Author: £exa

You can download the archive here:
http://www.elderscrollsportal.de/ressourcen/3025/...

Title: Skyrim Map Markers

Version: 1.2
Author: Leonardo

*Deleted*

Readme:

*Removed*

Title: Feyiin's Troubles

Version: 1.1
Author: Danae
...

Title: Lucky Coins

Version: 1.0
Author: Danae

Download: ...